Product Name :
3,3′,5,5′-Tetraiodothyroacetic acid (CAS 67-30-1)
Synonym :
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzeneacetic acid; Tetrac
Application :
CAS:
67-30-1
Purity:
≥98%
Molecular Weight:
747.83
Formula :
C14H8O4I4
Physical state:
Solid
solubility :
Soluble in acetone (20 mg/mL).
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(=O)O
References:
:Inhibition of the activity of the native gamma-aminobutyric acid A receptor by metabolites of thyroid hormones: correlations with molecular modeling studies. | Martin, JV., et al. 2004. Brain Res. 1004: 98-107. PMID: 15033424Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution. | Neumann, P., et al.30830-27-4 MDL No. 2005. Acta Crystallogr D Biol Crystallogr. 61: 1313-9. PMID: 16204882Protective effect of 3,5,3′-triiodothyroacetic and 3,5,3′,5′-tetraiodothyroacetic acids on serum albumin fibrillation. | Cortez, LM., et al. 2009. Eur Biophys J. 38: 857-63. PMID: 19381627Characterization of iodothyronine sulfotransferase activity in the cytosol of Rana catesbeiana tadpole tissues. | Rahman, FB. and Yamauchi, K. 2010. Gen Comp Endocrinol. 166: 396-403. PMID: 20036241Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro. | Ishibashi, H., et al. 2013. Brain Res. 1490: 1-8. PMID: 23103412Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8.2649400-34-8 Formula | Horn, S.PMID:33686748 , et al. 2013. Endocrinology. 154: 968-79. PMID: 23307789Inherited defects of thyroid hormone-cell-membrane transport: review of recent findings. | Fu, J., et al. 2013. Curr Opin Endocrinol Diabetes Obes. 20: 434-40. PMID: 2397477264Cu-Labeled tetraiodothyroacetic acid-conjugated liposomes for PET imaging of tumor angiogenesis. | Kang, CM., et al. 2013. Nucl Med Biol. 40: 1018-24. PMID: 24035550Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy. | Fernando, R., et al. 2017. J Clin Endocrinol Metab. 102: 776-785. PMID: 27768856Combined Treatment of Heteronemin and Tetrac Induces Antiproliferation in Oral Cancer Cells. | Huang, CH., et al. 2020. Mar Drugs. 18: PMID: 32630719Nano-Strategies Targeting the Integrin alpha v beta 3 Network for Cancer Therapy. | Cheng, TM., et al. 2021. Cells. 10: PMID: 34359854Uptake of 3,3′,5,5′-tetraiodothyroacetic acid and 3,3′,5′-triiodothyronine in cultured rat anterior pituitary cells and their effects on thyrotropin secretion. | Everts, ME., et al. 1995. Endocrinology. 136: 4454-61. PMID: 7664665