Product Name :
STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78]
Predicted band size :
90 kDa
Observed band size :
90 kDa
Synonyms:
Mammary gland factor (STAT5A) antibody MGF (STAT5A) antibody Signal transducer and activator of transcription 5A antibody Signal transducer and activator of transcription 5B antibody STA5A_HUMAN antibody Stat 5a antibody STAT 5b antibody STAT5A antibody Transcription factor STAT5B antibody
Function :
Stat5 (Signal Transducers and Activators of Transcription 5) is important in regulating T cell functions involving the receptors for Interleukin-2 (IL-2). IL-2 stimulates the rapid phosphorylation of both serine and tyrosine residues of Stat5a and Stat5b in human T lymphocytes and in several IL-2-responsive lymphocytic cell lines. IL-2 differentially induces serine phosphorylation of Stat5a and Stat5b on Ser726 and Ser731, respectively. Stat5b is preferentially phosphorylated and displays more protracted serine phosphorylation kinetics than Stat5a. Both the acid-rich region and the COOH terminus of IL-2Rb can independently mediate IL-2-induced Stat 5a/b serine phosphorylation, suggesting that Stat5a/b serine phosphorylation occurs at a postreceptor level. Stat5a is phosphorylated on Tyr694 in a prolactin-sensitive manner, whereas serine phosphorylation is constitutive.Desmosterol Order Activation of Stat5 by IL-2 may help govern the biological effects of IL-2 during the immune response.5-Chloro-2-methyl-4-pyridinol Chemical name
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within mouse Stat5b aa 585-773 / 786.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Coupling :
unconjugated
Clone number:
JJ08-78
RRID:
AB_3070213
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33433307 Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 90 kDa
Positive control :
Jurkat cell lysate,PC-12 cell lysate,HepG2 cell lysate,NIH/3T3 cell lysate,RH-35 cell lysate,HeLa cell lysate,HepG2, NIH/3T3, RH-35, human tonsil tissue, human spleen tissue, mouse brain tissue.