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Telomeres are hugely conserved regions of repetitive nucleotide sequences (TTAGGG) that shield the ends of chromosomes.1 The Ladies Overall health Initiative program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Wellness, U.S. Division of Overall health and Human Services through contracts N01WH22110, 24152, 32100, 32105, 32108, 321113, 32115, 32118, 32122, 421076, 421292, and 44221. This ancillary study was supported by a grant from the National Institute of Diabetes and Digestive and Kidney Ailments R21 DK084452 and the Burroughs Wellcome Fund. Yan Song is actually a recipient of fellowship from the UCLA Burroughs Wellcome Fund Interschool Coaching Plan in Metabolic Illnesses. two Author disclosures: Yan Song, N.C. Y. You, Yiqing Song, M. K. Kang, L. Hou, R. Wallace, C. B. Eaton, L. F. Tinker, and S. Liu, no conflicts of interest. three Supplemental Tables 1 and two are accessible in the “Online Supporting Material” link within the on the internet posting of the short article and in the very same link inside the online table of contents as http://jn.nutrition.org. To whom correspondence need to be addressed. E mail: [email protected] length (TL)15 decreases over time due to cell division and may well serve as a biomarker for the aging method and some agerelated complex ailments (1). Whereas the precise mechanism figuring out TL remains incompletely understood, dietary things may possibly play a crucial part in influencing the price of telomere shortening (2,three). Quite a few reports have connected “dietary scores” with TL (four,5), including a recent crosssectional study in 1942 European males that linked intakes of total fat and SFAs to TL (six). Within a smaller intervention trial in 47 women, modifications in dietary fat intake appeared to also negatively affec.
