Product Name :
hSET1/SET1 Recombinant Rabbit Monoclonal Antibody [PH00-02]
Predicted band size :
186 kDa
Observed band size :
300 kDa
Synonyms:
Histone-lysine N-methyltransferase SETD1A antibody hSET1A antibody KMT2F antibody Lysine N methyltransferase 2F antibody Lysine N-methyltransferase 2F antibody SET domain containing 1A antibody SET domain containing protein 1A antibody SET domain-containing protein 1A antibody SET1 antibody Set1 Ash2 histone methyltransferase complex subunit SET1 antibody 展开
Function :
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of ‘Lys-4’ of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place.Buy248274-16-0 Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis.1-Ethynyl-3,5-difluorobenzene Formula Required for H3K4me1 mark at stalled replication forks.PMID:33729095 Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate ‘Lys-4’ of histone H3 if the neighboring ‘Lys-9’ residue is already methylated.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within C terminal human SET1A.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, FC
Coupling :
unconjugated
Clone number:
PH00-02
RRID:
AB_3072346
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 186 kDa
Positive control :
293T cell lysates, 293T, HepG2.